Just tested with another Intel NUC (D54250WYK with i5-4250U and Intel HD Graphics 5000) and it is working!
It has OPENGL 4.5 and avx2 (the Systems before (i5-3427U and Pentium G4500), did not have avx2 under System Settings, Information).
Played a bit with GTA III and found out, that the D-Pad does not work in game (according to ingame Options, it should be possible to move with D-Pad and Analog-Stick, but only the Analog-Stick works for moving in game. I'm using original Sony PS3-Controller).
It also works on my Asus Zenbook UX305CA with m7-6Y75 CPU and Intel HD Graphics 515 (opengl 4.5 and also avx2).